We came across a novel block deletion of 9 nucleotides preceding the AC-repeat region in HVS-III. This changes the earlier SAM2 alignment in that region (see figure below) and leads to a phylogenetically more plausible alignment.
We have updated the database with 8,227 new haplotypes from 26 different countries (including 5 updates from CR to full mitogenome).
The tolerance level of EMMA was downsized from 0.3 to 0.1 to allow for a finer haplogroup estimation of mtDNA haplotypes. Extensive testing on a data set comprising 86,048 haplotypes suggested that this reduction would be beneficial for forensically relevant haplogrouing. Especially haplotypes previously assigned to haplogroups H, L3 and M benefit from a more accurate classification.
EMPOP 3 represents a new mtDNA database version based on a novel programming concept and website layout. New features are included to accommodate Massively Parallel (Next Generation) Sequencing data.